|Natural Product Number|
Grapefruit seed extract is a product derived from the seeds, pulp, and white membranes of grapefruit. Several chemical researches have revealed the presence of flavonoids, ascorbic acid, tocopherols, citric acid, limonoids, sterols and minerals in the seeds and pulp of grapefruit. All these substances are highly active against many types of parasites, viruses, molds and bacteria from different sources. Grapefruit seed extract also shows anti-inflammatory and antioxidant properties that inhibit free radical damage. Grapefruit seed extract reduces symptoms of many health disorders such as eczema, rheumatic pain, influenza, gastroenteritis, allergies, ulcers and parasitic diseases. Grapefruit seed extract also maintains healthy gastrointestinal conditions. Most importantly, grapefruit seed extract was shown to be as effective as some antibiotics.
Several reports have demonstrated the activity of grapefruit seed extract against several fungi and bacteria. A study described the antibacterial and antifungal activity of grapefruit seed extract against Gram-positive (Staphyllococcus and Enterococcus) and Gram-negative (Pseudomonas) bacteria. Another study analyzed the antibacterial and antifungal properties of grapefruit seed extract against 20 bacterial and 10 yeast strains. The grapefruit seed exhibited a strong antimicrobial effect against Salmonella enteritidis. The mechanism for grapefruit seed extract’s antibacterial action is piercing the bacterial membrane, thereby releasing the cytoplasmic contents. Also, the active ingredients of this extract disorganize cell membranes of microorganisms, which makes the absorption of amino acids impossible.
Flavonoids, contained in the grapefruit seed extract, exert their powerful antioxidant action by their antiradical, antilipoperoxidation and metal chelation activity. In a study, the antioxidant activities of grapefruit seed extract, which contains tocopherols, citric and ascorbic acids, were examined in vegetable oils. This extract showed its prooxidant properties at 97.8 °C and 75 °C, possibly due to a blockade effect of a hydroxyl compound by tocopherol. Another study confirmed that grapefruit seeds delivered a higher antioxidant effect than the peel. In addition to having antioxidant properties, grapefruit seed extract reduces the symptoms of many health disorders conditions such as eczema, rheumatic pain, influenza, gastroenteritis, allergies, ulcers and parasitic diseases.
The flavonoids in grapefruit seed extract have many valuable effects, such as the prevention of cardiovascular disease and certain types of cancer. This compound acts by inhibiting the proliferation of cancer cells, by preventing carcinogens from reaching critical initiation sites, and by supporting the mechanisms that help to metabolize carcinogens into other less toxic materials.
A study has linked the anti-inflammatory action of grapefruit seed extract to its ability to inhibit many regulatory enzymes (protein kinase C, phosphodiesterase, phospholipase, lipoxygenase and cyclooxygenase). This extract also affects the activation of numerous cells involved in the immune response, such as T and B lymphocytes.
A study showed that grapefruit seed extract is effective to inhibit the proliferation of candidiasis. An in vivo study demonstrated beneficial effects in the microflora of individuals suffering from atopic dermatitis (atopic eczema).
Hesperidin is often used to help treat vascular conditions such as hemorrhoids and varicose veins. This flavonoid improves venous tone, reduces stasis, restores normal capillary permeability, and improves lymphatic drainage. Furthermore, hesperidin restores normal permeability of capillaries through its anti-inflammatory effect and increases lymphatic drainage.
Pharmacokinetic: Flavonoids are taken up and metabolized by the gastrointestinal tract where, once absorbed, they get converted to conjugates and metabolites, their bioactive form. Cells from the small intestine transfer the flavonoids from the gut lumen to the portal vein, where they are further metabolized. The polyphenols, once conjugated and metabolized, are then ready to enter the systemic circulation and the liver. Microflora from the colon also degrades the flavonoids into small phenolic acids, which can then be used. These metabolites, when not absorbed by the cells, are excreted through urine.
Do not put in eyes or use full strength in mouth, ears, nose, or sensitive areas. May cause irritation if used directly on the skin.
Shake well. Adults: Mix 12–15 drops in a glass of water or juice, one to four times daily, with or without meals, or as directed by your health-care practitioner.
Cautions and warnings:
Cautions and warnings: Consult a health-care practitioner prior to use if you are taking other medications or if you are pregnant or breast-feeding. Do not put in eyes. Do not use full strength in mouth, ears, nose or sensitive areas. May cause irritation if used directly on the skin.
|Each drop contains:|
|Grapefruit seed extract (560 mcg of vitamin C per drop)||7 mg|
|Other ingredient: Vegetable glycerin.|