|Natural Product Number|
The effective functioning of the human digestive process requires the coordinated secretion, delivery, and action of a variety of chemical substances. However, digestive disorders resulting in the malabsorption of food components may arise, and can be caused by many things: cystic fibrosis, chronic pancreatitis, pancreatic resection, or stomach cancer, to name a few. Digestive Enzymes is a blend of enzymes, present in both the stomach and the small intestine, aimed at facilitating digestion. It contains pancreatin, a mix of pancreatic enzymes including protease for the hydrolysis of proteins, amylase for the degradation of starches, and lipase for the digestion of fats. Digestive Enzymes also comprises ox bile salts to aid in gut-fat absorption, and papain, a plant-derived proteolytic enzyme. Furthermore, betaine hydrochloride is found in this supplement; it is a source of hydrochloric acid, which acts in the gastrointestinal tract to activate pepsin, aids in the secretion of pancreatic juices, and allows the absorption of certain inorganic salts.
Pancreatin is a lyophilized extract of porcine pancreatic tissue containing the pancreatic enzymes protease, amylase, and lipase. Pancreatin enzyme supplementation is particularly useful in exocrine pancreatic insufficiency, and is also a valuable part of treatment for a number of gastrointestinal conditions, including cystic fibrosis, altered gut anatomy postresection, some cases of short bowel syndrome, and celiac disease.
Pancreatin is especially useful for EPI (exocrine pancreatic insufficiency), which is a deficiency in the production and/or secretion of pancreatic enzymes needed for proper digestion. In patients with EPI, pancreatin delivers pancreatic enzymes to the small intestine, where they help metabolize fats, proteins, and carbohydrates in ingested food.
Betaine hydrochloride is a nutritional supplement source of hydrochloric acid. Hydrochloric acid is an acid found in digestive juices that’s involved in the production of the enzyme pepsin, an enzyme involved in protein digestion. Hydrochloric acid also activates important enzymes and hormones, and protects against bacterial overgrowth in the gut. betaine hydrochloride has been shown to be effective in relieving symptoms associated with achlorhydria and hypochlorhydria. It has been used for over 100 years to safely restore normal gastric acidity and to support healthy gut function, and is an alternative to acid-blocker drugs and over-the-counter antacids in the treatment of hypochlorhydria.
The administration of betaine hydrochloride increases secretin responses, resulting in better protein digestion. In examining the effects of administration of betaine hydrochloride on digestive enzyme secretion in gastrectomy patients (proximal gastrectomy, distal gastrectomy, and total gastrectomy) who did not receive betaine hydrochloride, it was showed that gastrin and secretin responses were decreased. However, cases of total gastrectomy given betaine hydrochloride with the test meal showed increased secretin responses.
Ox Bile Salts
Ox bile salts are naturally occurring, unoxidized, conjugated bile salts derived from ox bile. Ox bile salts are useful in promoting the intestinal absorption of food fats and certain fat-soluble vitamins (carotene and vitamins D, E, and K), when failure to absorb these substances is due to lack of bile in the intestine. Research shows that ox bile salts also enhance the intestinal absorption of vitamin K in jaundiced patients.
Ox bile salts increase the secretion of bile and tend to “thicken” it; a choleretic effect. There is an increase in the content of the various bile salts, but this is due to the bile salts ingested and not to any stimulation of the liver to produce bile salts. Elimination of cholesterol is augmented and excretion of bile pigments is not influenced. Choleretics given orally, such as ox bile salts, are generally credited with a slight laxative action, with stimulating intestinal motility, with facilitating the absorption of calcium, and with enhancing the efficiency of the resinous hydragogue cathartics.
Papain is an enzyme obtained from the latex of the papaya, Carica papaya. It is an enzyme of the hydrolase class that catalyzes the hydrolysis of proteins and peptides. It is primarily indicated in conditions like constipation, indigestion, pain, and inflammation. Papain in doses of 0.325 and 0.75 mg/kg possesses strongly marked anti-inflammatory activity, and this ability is no less than that of the NSAIDs butadion and indomethacin.
Papain plays an important role in the hydrolysis of proteins. Papain acts as a catalyst to form the products from the protein substrates, and is regenerated in its original form at the end of the reaction processes. The reaction is divided into two steps: acylation and deacylation. An anionic tetrahedral intermediate is formed between the two steps.
Pepsin is a digestive enzyme present in stomach juice. Oral pepsin is used clinically to aid digestion and absorption of food when patients have deficiency of its secretion. Pepsin is primarily indicated in conditions like dyspepsia.
One of the components of protein digestion requires the conversion of the gastric zymogen pepsinogen into active enzyme pepsin, a process known as zymogen activation. Zymogen activation requires the proteolytic cleavage of the prosegment from the N‑terminus of the zymogen and the dissociation of the cleaved prosegment from the active enzyme. Exogenous pepsin has been shown to accelerate porcine recombinant pepsinogen activation. Thus, oral pepsin acts in the stomach to hydrolyze proteins into polypeptides and amino acids, and thus acts in concert with the bromelain and proteolytic enzymes to restore and maintain the body’s amino acid balance.
This formula contains more papain than our Digestive Enzymes Plus formula, which contains more pancreatic enzymes.
Adults 18+: Take 1–3 capsules daily with food or as directed by your health-care practitioner. Take with or immediately before a meal/food. Swallow whole; do not crush or chew. Use the smallest effective dose which controls symptoms.
Cautions and warnings:
Cautions and warnings: Consult a health-care practitioner prior to use if you have heart or kidney problems; if you are suffering from any serious illness or disease; if you have allergy to latex or fruits (such as avocado, banana, chestnut, passion fruit, fig, melon, mango, kiwi, pineapple, peach, or tomato); if you have gastrointestinal lesions/ulcers, are taking anticoagulant agents, anti-inflammatory agents or other enzyme products, or are having surgery; if you have pancreatitis, pancreatic exocrine insufficiency, or cystic fibrosis; if you have diabetes; if you have cardiovascular disease; or if you have a peptic ulcer or excess stomach acid. Consult a health-care practitioner if the symptoms persist or worsen.
Contraindications: Do not use if you are pregnant or breast-feeding; after recent surgery; if you are sensitive to pancreatic enzymes; or if you are sensitive to pork proteins.
Known adverse reactions: Hypersensitivity/allergy have been known to occur; in which case, discontinue use. Nausea, vomiting, constipation, diarrhea, abdominal pain/epigastric pain, and/or heartburn have been known to occur; in which case discontinue use and consult a health-care practitioner.
|Each vegetable capsule contains:|
|Pancreatic enzymes (Sus scrofa pancreas)||11.4 mg|
|Betaine hydrochloride||105.3 mg|
|Ox bile (Bos taurus liver) extract (10:1)||64.8 mg|
|Papain (Carica papaya fruit) isolate||24 mg (2,400,000 FCC PU)|
|Pepsin isolate||32.4 mg (324,000 FCC pepsin)|
|Other ingredients: Vegetable magnesium stearate and silicon dioxide in a non‑GMO vegetable capsule composed of vegetable carbohydrate gum and purified water.|