|Natural Product Number|
Cholest is a comprehensive nutritional approach to lower serum cholesterol and triglycerides, prevent excessive cholesterol production in the liver, and prevent oxidative damage to arterial walls. Cholest includes nutrients such as red yeast extract, gugulipids, beta‑glucans, green tea extract, and plant sterols to optimize your HDL:LDL ratio and meet nutritional demands associated with cardiovascular-disease risk prevention.
Standardized Gugulipids (2.5% Guggulsterones)
Gum guggul appears to be an effective agent in reducing low-density lipoprotein (LDL) and triglycerides, while increasing high-density lipoprotein (HDL). Gum guggul, obtained from the herb Commiphora mukul, is suggested for the treatment of atherosclerosis. It is the first hypolipidemic agent derived from plant source. Several studies have shown the effectiveness of gum guggul in lowering serum cholesterol by up to 27%.
There are several hypotheses to explain the observed cholesterol-lowering effects of gum guggul. Based on animal and in vitro studies, the following mechanisms have been proposed: as antagonist to nuclear hormones involved with cholesterol metabolism and bile acid regulation; enhanced uptake of LDL by the liver; increased biliary and fecal excretion of cholesterol; inhibition of cyclooxygenase and HMG‑CoA reductase; and stimulation of the thyroid gland. The active ingredient is a ketosteroid (guggulsterone) with binding to steroid receptors. It expresses antagonist binding to mineralocorticoid, glucocorticoid, and androgen receptors, and agonist activity to progesterone receptors.
Sterols and Sterolins
Phytosterols, or plant sterols, used in Cholest are derived from sunflower seeds (Helianthus annuus) and soybeans (Soja hispida). Phytosterols are known to compete with dietary cholesterol for absorption. There are over 40 phytosterols identified in nature, but the most abundant are beta‑sitosterol, stigmasterol, and campesterol.
A study demonstrated that appropriate intakes of phytosterols decreased levels of LDL by about 10%. Moreover, combined with a diet low in cholesterol and saturated fat, phytosterol supplementation reduced LDL by 20%. Phytosterols decrease serum cholesterol by various mechanisms. First, cholesterol in the intestine precipitates into a nonabsorbable state in the presence of added phytosterols, thus inhibiting its absorption into circulation. Second, biliary micelles will uptake phytosterols more readily and preferentially than cholesterol, thus decreasing the reabsorption of cholesterol into circulation. A study has shown that plant sterols reduced the absorption of cholesterol by 25–50%. The HDL:LDL ratio was subsequently improved, which resulted in reduced risk of cardiovascular disease and improved cardiovascular health. A study confirmed that long-term consumption of 1.4–2.0 g/d of phytosterols reduced the incidence of myocardial ischemia by about 12–20% over five years and 20% over lifetime. Cholest provides the adequate dose.
Oat fibre (22% beta-Glucans)
beta‑Glucans are major components in cell walls of certain plants such as oats. Mammals cannot absorb beta‑glucans because they do not secrete the enzyme beta‑1,3‑glucanase needed to break down large beta‑glucan molecules. beta‑Glucans form a layer adjacent to the mucous membranes of the intestinal walls, thereby preventing the absorption of cholesterol.
In the intestines, beta‑glucans bind to bile acids, which are released with cholesterol and promote its excretion. Research suggests that the viscous properties of beta‑glucans may increase production of bile acid, which are responsible for cholesterol excretion. A study showed that supplementation with beta‑glucan for a seven‑ to eight‑week period decreased total serum cholesterol by 6–8% in subjects with hypercholesterolemia. Furthermore, four weeks after treatment, the concentration of HDL increased by 16%.
Green Tea Extract (50% Polyphenols)
Preliminary research suggests green tea has beneficial effects on blood lipids in individuals with hypercholesterolemia.
Green tea is a rich source of polyphenols known as flavonoids. The predominant flavonoids in green tea, catechins, have been shown to lower plasma cholesterol in both animal and human studies. A preliminary study in rats demonstrated that a green-tea-supplemented diet induced significant decreases in total cholesterol, LDL, and triglyceride levels. Green tea extract is a powerful antioxidant and may provide protection from arterial damage due to high cholesterol by inhibiting LDL oxidation.
Red Yeast Powder
Red yeast powder promotes and maintains healthy cholesterol levels and inhibits cholesterol production. It is made of red yeast (Monascus purpureus) cultivated on rice.
Red yeast rice inhibits HMG‑CoA enzyme, found in the liver, and regulates cholesterol production. Monacolin is the best known component of red yeast rice, and is the active compound to which are assigned the anticholesterol effects. Monacolin K, an inhibitor of cholesterol synthesis, is a secondary metabolite of the Monascus species and is affected by the environment and the culture method. Studies indicate that red yeast rice may lower LDL-cholesterol up to 10–33%.
Adults: Take 2 softgels twice daily with food or as directed by your health-care practitioner.
Duration of use: Consult a health-care practitioner for use beyond 8 weeks.
Cautions and warnings:
Cautions and warnings: Consult a health-care practitioner prior to use if you have a liver disorder; if you have an iron deficiency; if you have a thyroid disorder; if you are taking beta-blockers (e.g. propranolol) or calcium channel blockers (e.g. Diltiazem); if you have coagulation disorder and/or are at risk for bleeding; or if you are taking anticoagulant or antiplatelet medication. Could cause a dermatologic hypersensitivity reaction in some patients. Do not take if you have a known allergy/hypersensitivity to guggul or any of its constituents. Do not use if you pregnant or breast-feeding. Discontinue use if gastrointestinal discomfort, headache, and/or skin rash appear. Discontinue use and consult a health-care practitioner if you develop symptoms of liver trouble such as yellowing of the skin/eyes (jaundice), stomach pain, dark urine, sweating, nausea, unusual tiredness, and/or loss of appetite. Rare, unpredictable cases of liver injury associated with green tea extract–containing products have been reported.
|Each softgel contains:|
|Guggul (Commiphora wightii), 3.5% guggulsterone||350 mg|
|Free plant sterols (from soy)||200 mg|
|Oat (Avena sativa), 22% beta-glucans||150 mg|
|Red yeast rice (Monascus purpureus)||50 mg|
|Green tea (Camellia sinensis) extract, 50% polyphenol||80 mg|
|Other ingredients: Extra virgin olive oil, beeswax, silicon dioxide and sunflower lecithin in a softgel made of bovine gelatin and glycerin, with annatto extract (in sunflower oil) and purified water.|