|Natural Product Number|
Boswellia and curcumin are well-known anti-inflammatory herbs, known for their ability to inhibit the cyclooxygenase (COX‑2) and lipooxygenase (LOX) enzyme pathways. These enzymes are responsible for the conversion of arachidonic acid to the proinflammatory mediators prostaglandins E₂ (PGE₂) and leukotrienes LT₄. These inflammatory pathways are upregulated in a host of inflammatory conditions, including:
· rheumatoid arthritis;
· acute musculoskeletal injuries;
· chronic pain conditions;
· inflammatory bowel disease; and
COX‑1 is a constitutively expressed enzyme; however, COX‑2 is rapidly induced by stimuli including cytokines, growth factors, and tobacco carcinogens, meaning that it is responsive to the state of the body’s internal environment. Chemicals secreted by tumour cells and their microenvironment are known to upregulate COX‑2, and it is thought that this enzyme is a central player in cancer initiation, growth, and metastasis. Cancer prevention through use of anti-inflammatory, COX‑inhibiting drugs is under investigation.
Role in Cancer Therapy
Chronic inflammation contributes powerfully to cancer development and progression. Levels of specific inflammatory markers have been correlated with tumour size and aggressiveness, and elevated levels have been shown to predict cancer prognosis. For example, CRP is a measure of systemic inflammation; an inflammation-based prognostic score measuring CRP and hypoalbuminemia has been shown to predict worse outcomes for survival in gastric cancer patients, cervical cancer patients, and colorectal cancer patients.
A 2011 meta-analysis of CRP as a prognostic marker in breast-cancer patients found that CRP was able to predict overall and disease-free survival, HRs 1.62 (95% CI 1.20 to 2.18) and 1.81 (95% CI 1.44 to 2.26), respectively.
At the cellular level, the COX‑2 product PGE₂ impacts a wide range of targets including cell proliferation, apoptosis, angiogenesis, inflammation, and immune surveillance. The COX‑2/PGE₂ pathway is often observed to be upregulated in human cancers, and has been shown to activate hormonal pathways implicated in cancer such as aromatase/estrogen in breast tissue. Suppression of PGE₂ production in animal models has been shown to dramatically reduce tumour load (tumour number and size), and upregulate T‑regulatory cells which may play a role in tumour suppression. This has fuelled the investigation of NSAIDs and COX‑2 inhibitors as possible cancer-preventive agents; however, although these drugs seem effective, long-term use is limited by their potential for gastrointestinal toxicity and cardiovascular risk.
Vitazan Professional’s Can‑Arrest combines four natural ingredients that have been proven to reduce inflammation by inhibiting COX‑2 and other enzymes.
Management of Inflammatory Conditions and Alleviation of Pain
Curcumin has been shown to improve WOMAC* (pain, stiffness, physical function) in patients with osteoarthritis, and also reduced a series of inflammatory markers including CRP, IL‑6, and ESR.
Boswellia has been shown to reduce WOMAC and markers of inflammation in patients with osteoarthritis. Improvements were seen as early as five days.
Quercetin has been shown to reduce markers of inflammation and oxidative stress in patients with sarcoidosis, an inflammatory disease.
Bromelain administration of a bromelain-based enzyme product to a group of patients with acute ankle sprain significantly reduced pain in over 73% of participants after seven days. In addition, a study of patients undergoing dental surgery found that administration of bromelain was able to reduce postoperative pain and swelling.
*WOMAC = Western Ontario and McMaster Universities Arthritis Index : index de sévérité symptomatique de l’arthrose des membres inférieurs.
Adults: Take 2 capsules three times daily at meals or as directed by your health-care practitioner.
Duration of use: Consult a health-care practitioner for use beyond 4 weeks.
Cautions and warnings:
Cautions and warnings: Consult a health-care practitioner prior to use if you have gallstones or a bile duct obstruction; if you are taking any prescription medications; if you have gastrointestinal lesions/ulcers; if you are taking anticoagulant agents, anti-inflammatory agents, or antibiotics; or before having surgery. Consult a health-care practitioner if symptoms persist or worsen.
Contraindications: Do not use if you are pregnant or breast-feeding. Do not use if you are allergic to pineapple or Asteraceae/Compositae plant family.
Known adverse reactions: Hypersensitivity/allergy has been known to occur; in which case, discontinue use. Nausea, vomiting, and diarrhea have been known to occur; in which case discontinue use and consult a health-care practitioner.
Note: Do not use while on chemotherapy, as curcumin may interfere with chemotherapy drugs. Stop taking Can‑Arrest two days before chemotherapy. Resume taking Can‑Arrest only 30 days after your last chemotherapy treatment has ended.
|Each vegetable capsule contains:|
|Boswellia (Boswellia serrata), 35% boswellic acid, 70% organic acids||200 mg|
|Turmeric (Curcuma longa) root extract, 95% curcuminoids, providing curcumin I, demethoxycurcumin, and bisdemethoxycurcumin||200 mg|
|Bromelain (2400 GDU/g), 3,600,000 FCC papain units||100 mg|
|Other ingredients: Vegetable magnesium stearate and silicon dioxide in a non‑GMO vegetable capsule composed of vegetable carbohydrate gum and purified water.|