|Natural Product Number|
Black cumin, also known as Nigella sativa, is an herb with a long history of use for an impressively wide range of health conditions. Black cumin has been used as crushed seed, oil, and as a water extract. One of the identified active ingredients in black cumin is thymoquinone, a compound that is known to have anti-inflammatory and antioxidant effects. Black cumin oil also contains plant sterols, as well as 25% oleic acid, 55% linoleic acid, and volatile oils including thymol, limonene, and carvacrol.
In humans, black cumin has been shown to have antidiabetic, blood-pressure-, and cholesterol-lowering effects. It also has activity against specific types of infection, possesses antiallergic effects, and improves rheumatoid arthritis as well as pediatric seizures.
Adults: Take 2 softgels twice daily before a meal or as directed by your health-care practitioner. Take with food. If you are taking supplements containing iron, zinc, calcium, or copper, take this product a few hours before or after them.
Duration of use: Consult a health-care practitioner for use beyond 4 weeks.
Cautions and warnings:
Cautions and warnings: Consult a health-care practitioner prior to use if you have a known immune disorder, if you have hypertension or hypotension, and/or if you are taking antihypertensive agents. Discontinue use if you experience gastrointestinal upset. Discontinue use and consult a health-care practitioner if symptoms persist or worsen.
Contraindications: Do not take if you are pregnant, breast-feeding, or trying to conceive.
Known adverse reactions: May cause gastrointestinal upset when taken on an empty stomach.
|Each softgel contains:|
|Organic black cumin (Nigella sativa) seed oil, 50% linoleic acid, 20% oleic acid||500 mg|
|Other ingredients: Mixed tocopherol concentrate (from sunflower) in a softgel made of bovine gelatin, glycerin, and purified water.|
Human Trials of Black Cumin Seed Oil
n = 88 subjects with TC > 200 mg/dL
|2 g crushed black cumin seeds or placebo (in 500 mg caps) × 4 weeks||Significant decreases in TC (4.78%), LDL (7.6%), TG (16.65%).|
No change in fasting glucose or HDL.
|Type 2 diabetes||RCT of 3 black cumin doses, no placebo; n = 94 patients on medication with insufficiently controlled glucose||Black cumin seeds at 1, 2, or 3 g daily × 3 months||The 2 g‑dose group had significant reductions in fasting glucose, 2 h postprandial glucose, and HbA1c, without significant change in body weight.|
The 1 g‑dose group showed nonsignificant trends toward improvement, while the 3 g‑dose group had no advantage over 2 g.
n = 40 obese men with no more than stage I hypertension and normal or impaired glucose
|1.5 g black cumin seed or placebo × 3 months||Body weight, waist circumference, and systolic blood pressure decreased in the black cumin group only (p < 0.05 for all compared to baseline), while these increased in the placebo group:|
· body weight 77 kg → 72 kg at 3 months;
· waist circumference 101 → 99.8 cm;
· and systolic BP 130 → 121.
|Metabolic syndrome components||RDBPCT;|
n = 123 patients
|Black cumin seed (dose not reported), or placebo||“Favorable impact of powdered N. sativa (Kalonji) seed in capsule was noted on almost all variables [body-mass index, waist-hip ratio, blood pressure, fasting blood sugar, lipids, ALT, and creatinine], but results were not statistically significant because of small sample size.”|
n not reported; patients with “mild hypertension”
|100 or 200 mg black cumin extract twice daily × 8 weeks, or placebo||There was a reduction in systolic and diastolic blood pressure in both black cumin groups, in a dose-dependent manner, that was significant compared to placebo (p < 0.05 for all). In addition, there was a significant reduction in TC and LDL compared to baseline in the black cumin group (p value not reported).|
n = 66 patients
|Black cumin oil × 30 days (dose not reported), or placebo||Black cumin reduced the presence of the nasal mucosal congestion, nasal itching, runny nose, sneezing attacks, turbinate hypertrophy, and mucosal pallor within the first 2 weeks of treatment.|
n = 29 asthma patients
|15 mL/kg of 0.1 g% boiled aqueous extract daily × 3 months, or placebo solution||In the black cumin group the following symptoms improved significantly 3 months compared with baseline and with placebo: asthma symptoms, frequency of asthma symptoms per week, chest wheezing, and pulmonary function tests.|
Requirements for medications decreased in the black cumin but not in the placebo group.
|Allergy||Report of 4 trials;|
n = 152 patients with allergic diseases (allergic rhinitis, bronchial asthma, atopic eczema)
|Black cumin oil: 40–80 mg/kg/d||Subjective report of symptoms severity improved with black cumin treatment.|
|Helicobacter pylori and dyspepsia||RCT;|
n = 88 patients with dyspepsia and positive H. pylori breath test
|4 groups: i) triple therapy or ii) 1, 2, or 3 g black cumin in addition to omeprazole × 4 weeks; black cumin as ground seed.||H. pylori eradication was 82.6, 47.6, 66.7 and 47.8% with triple therapy, and 1 g, 2 g, and 3 g Nigella, respectively. Eradication rates with 2 g black cumin + omeprazole and triple therapy were not statistically different.|
Dyspepsia symptoms improved in all groups to a similar extent.
n = 200 patients with acute tonsillo-pharyngitis
|Combination of black cumin 360 mg and Phyllanthus niruri 50 mg extract 3×/d × 7 days, or placebo||The black cumin extract led to relief of the pain and difficulty of swallowing within a few hours after the first dose. After 7 days, a significantly greater proportion of patients in the black cumin group had their sore throat completely relieved.|
|Rheumatoid arthritis||PCT, ×-over;|
n = 40 female RA patients; all were on combined drug therapy.
|1 g black cumin oil or placebo (in 500 mg caps) × 1 month||Disease activity improved in 42.5% and 30% of the patients respectively after black cumin.|
The number of swollen joints and the duration of morning stiffness also improved.
|Pediatric seizure||DBPCT ×-over;|
n = 22 children with refractory epilepsy
|1 mg/kg thymoquinone from black cumin seed or placebo × 4 weeks||Thymoquinone treatment resulted in a significant reduction in seizure frequency compared to placebo (p = 0.04).|
n = 40 chemical war victims with respiratory symptoms
|0.375 mL/kg of 50 g% boiled aqueous black cumin extract daily × 2 months, or placebo||At study end, pulmonary function tests and respiratory symptoms were significantly improved in the black cumin group compared to the control group (p < 0.01 to p < 0.001). Requirements for medication were decreased in the black cumin but not the placebo group.|
Explanation of abbreviations
|RPCT: Randomized, placebo-controlled trial|
RCT: Randomized, controlled trial
RDBPCT: Randomized, double-blind, placebo-controlled trial
DBPCT: Double-blind, placebo-controlled trial
|PCT: Placebo-controlled trial|
TC: Total cholesterol
LDL: Low-density lipoprotein