Black Cumin Seed Oil 500 mg

Black Cumin Seed Oil 500 mg
Size

60 softgels

Natural Product Number

80041774

Black cumin, also known as Nigella sativa, is an herb with a long history of use for an impressively wide range of health conditions. Black cumin has been used as crushed seed, oil, and as a water extract. One of the identified active ingredients in black cumin is thymoquinone, a compound that is known to have anti-inflammatory and antioxidant effects. Black cumin oil also contains plant sterols, as well as 25% oleic acid, 55% linoleic acid, and volatile oils including thymol, limonene, and carvacrol.
In humans, black cumin has been shown to have antidiabetic, blood-pressure-, and cholesterol-lowering effects. It also has activity against specific types of infection, possesses antiallergic effects, and improves rheumatoid arthritis as well as pediatric seizures.

Description

Suggested Use

Adults: Take 2 softgels twice daily before a meal or as directed by your health-care practitioner. Take with food. If you are taking supplements containing iron, zinc, calcium, or copper, take this product a few hours before or after them.
Duration of use: Consult a health-care practitioner for use beyond 4 weeks.

Cautions and warnings:

Cautions and warnings: Consult a health-care practitioner prior to use if you have a known immune disorder, if you have hypertension or hypotension, and/or if you are taking antihypertensive agents. Discontinue use if you experience gastrointestinal upset. Discontinue use and consult a health-care practitioner if symptoms persist or worsen.
Contraindications: Do not take if you are pregnant, breast-feeding, or trying to conceive.
Known adverse reactions: May cause gastrointestinal upset when taken on an empty stomach.

Ingredients

Each softgel contains:
Organic black cumin (Nigella sativa) seed oil, 50% linoleic acid, 20% oleic acid500 mg
Other ingredients: Mixed tocopherol concentrate (from sunflower) in a softgel made of bovine gelatin, glycerin, and purified water.

Human Trials of Black Cumin Seed Oil

IndicationDesignDoseOutcome

Metabolic Syndrome

HyperlipidemiaRPCT;
n = 88 subjects with TC > 200 mg/dL
2 g crushed black cumin seeds or placebo (in 500 mg caps) × 4 weeksSignificant decreases in TC (4.78%), LDL (7.6%), TG (16.65%).
No change in fasting glucose or HDL.
Type 2 diabetesRCT of 3 black cumin doses, no placebo; n = 94 patients on medication with insufficiently controlled glucoseBlack cumin seeds at 1, 2, or 3 g daily × 3 monthsThe 2 g‑dose group had significant reductions in fasting glucose, 2 h postprandial glucose, and HbA1c, without significant change in body weight.
The 1 g‑dose group showed nonsignificant trends toward improvement, while the 3 g‑dose group had no advantage over 2 g.
Metabolic syndromeRDBPCT;
n = 40 obese men with no more than stage I hypertension and normal or impaired glucose
1.5 g black cumin seed or placebo × 3 monthsBody weight, waist circumference, and systolic blood pressure decreased in the black cumin group only (p < 0.05 for all compared to baseline), while these increased in the placebo group:
· body weight 77 kg → 72 kg at 3 months;
· waist circumference 101 → 99.8 cm;
· and systolic BP 130 → 121.
Metabolic syndrome componentsRDBPCT;
n = 123 patients
Black cumin seed (dose not reported), or placebo“Favorable impact of powdered N. sativa (Kalonji) seed in capsule was noted on almost all variables [body-mass index, waist-hip ratio, blood pressure, fasting blood sugar, lipids, ALT, and creatinine], but results were not statistically significant because of small sample size.”
HypertensionRDBPCT;
n not reported; patients with “mild hypertension”
100 or 200 mg black cumin extract twice daily × 8 weeks, or placeboThere was a reduction in systolic and diastolic blood pressure in both black cumin groups, in a dose-dependent manner, that was significant compared to placebo (p < 0.05 for all). In addition, there was a significant reduction in TC and LDL compared to baseline in the black cumin group (p value not reported).

Allergy

Allergic rhinitisDBPCT;
n = 66 patients
Black cumin oil × 30 days (dose not reported), or placeboBlack cumin reduced the presence of the nasal mucosal congestion, nasal itching, runny nose, sneezing attacks, turbinate hypertrophy, and mucosal pallor within the first 2 weeks of treatment.
AsthmaRPCT;
n = 29 asthma patients
15 mL/kg of 0.1 g% boiled aqueous extract daily × 3 months, or placebo solutionIn the black cumin group the following symptoms improved significantly 3 months compared with baseline and with placebo: asthma symptoms, frequency of asthma symptoms per week, chest wheezing, and pulmonary function tests.
Requirements for medications decreased in the black cumin but not in the placebo group.
AllergyReport of 4 trials;
n = 152 patients with allergic diseases (allergic rhinitis, bronchial asthma, atopic eczema)
Black cumin oil: 40–80 mg/kg/dSubjective report of symptoms severity improved with black cumin treatment.

Infection

Helicobacter pylori and dyspepsiaRCT;
n = 88 patients with dyspepsia and positive H. pylori breath test
4 groups: i) triple therapy or ii) 1, 2, or 3 g black cumin in addition to omeprazole × 4 weeks; black cumin as ground seed.H. pylori eradication was 82.6, 47.6, 66.7 and 47.8% with triple therapy, and 1 g, 2 g, and 3 g Nigella, respectively. Eradication rates with 2 g black cumin + omeprazole and triple therapy were not statistically different.
Dyspepsia symptoms improved in all groups to a similar extent.
Acute tonsillo-pharyngitisRDBPCT;
n = 200 patients with acute tonsillo-pharyngitis
Combination of black cumin 360 mg and Phyllanthus niruri 50 mg extract 3×/d × 7 days, or placeboThe black cumin extract led to relief of the pain and difficulty of swallowing within a few hours after the first dose. After 7 days, a significantly greater proportion of patients in the black cumin group had their sore throat completely relieved.

Miscellaneous

Rheumatoid arthritisPCT, ×-over;
n = 40 female RA patients; all were on combined drug therapy.
1 g black cumin oil or placebo (in 500 mg caps) × 1 monthDisease activity improved in 42.5% and 30% of the patients respectively after black cumin.
The number of swollen joints and the duration of morning stiffness also improved.
Pediatric seizureDBPCT ×-over;
n = 22 children with refractory epilepsy
1 mg/kg thymoquinone from black cumin seed or placebo × 4 weeksThymoquinone treatment resulted in a significant reduction in seizure frequency compared to placebo (p = 0.04).
Pulmonary functionRDBPCT;
n = 40 chemical war victims with respiratory symptoms
0.375 mL/kg of 50 g% boiled aqueous black cumin extract daily × 2 months, or placeboAt study end, pulmonary function tests and respiratory symptoms were significantly improved in the black cumin group compared to the control group (p < 0.01 to p < 0.001). Requirements for medication were decreased in the black cumin but not the placebo group.

Explanation of abbreviations

RPCT: Randomized, placebo-controlled trial
RCT: Randomized, controlled trial
RDBPCT: Randomized, double-blind, placebo-controlled trial
DBPCT: Double-blind, placebo-controlled trial
PCT: Placebo-controlled trial
TC: Total cholesterol
LDL: Low-density lipoprotein
TG: Triglycerides